Doctor Taking Notes

Publications & Presentations

Myoepithelioma of the salivary glands. Fine needle aspiration biopsy findings

PMID: 15192943


DOI: 10.1159/000326377

Abstract

Objective: To evaluate the cytologic findings and pitfalls in the diagnosis of myoepithelioma of the salivary glands.

Study design: Smears from 7 cases of myoepithelioma of the salivary glands, 3 plasmacytoid, 2 spindle and 2 mixed types, all histologically confirmed, were evaluated with special attention to cytologic features that may be helpful for the diagnosis.

Results: A correct cytologic diagnosis was not made in any of the cases. Three were diagnosed as plasmacytomas or cellular pleomorphic adenomas, 2 as benign spindle cell tumors and 2 as cellular pleomorphic adenomas. Mitoses and marked pleomorphism were absent. Nuclear striations were noted frequently.

Conclusion: Diagnosis of myoepithelioma was difficult on fine needle aspiration smears. Nuclear striations (zebra lines) were noted in 5 cases. This finding is not reported in previously published papers.

Association of red blood cell 5-methyltetrahydrofolate folate with bone mineral density in postmenopausal Iranian women

PMID: 16133647


DOI: 10.1007/s00198-005-1961-x

Abstract

Recent studies have suggested that hyperhomocysteinemia and low plasma folate are associated with fracture and also bone mineral density (BMD) and that they may contribute to the pathogenicity of osteoporosis in postmenopausal women. However, as plasma total homocysteine (tHcy) and plasma folate can be regarded as short-term markers when compared to a long-term variable such as BMD, in this study we tested the hypothesis that low red blood cell 5-methyltetrahydrofolate (RBC 5-MTHFR) as a long-term marker of the folate status may be a better predictor of BMD than plasma 5-MTHF, and its deficiency may contribute to the pathogenicity of osteoporosis in postmenopausal Iranian women. The BMD at the femoral neck and lumbar spine (measured by dual-energy X-ray absorptiometry, DXA) together with anthropometric and biochemical components of the homocysteine re-methylation pathway including plasma tHcy, 5-MTHF and vitamin B12, RBC 5-MTHF and creatinine were determined in 366 postmenopausal women. RBC 5-MTHF was more highly correlated with BMD at the lumbar spine (r=0.21, P=0.001) and femoral neck (r=0.19, P=0.004) than was plasma 5-MTHF (lumbar spine; r=0.14, P=0.03 and femoral neck; r=0.17, P=0.006). Stepwise multiple linear regression analyses revealed that RBC 5-MTHF was one of the predictors of BMD explaining 4.3 and 4.0% variance of BMD at the lumbar spine and femoral neck, respectively, whereas plasma 5-MTHF was excluded in the model and not determined to be a predictor of BMD at both the lumbar spine and femoral neck when adjusted for age, BMI, years since menopause and RBC 5-MTHF. This study suggests that RBC 5-MTHF is a better predictor of BMD than plasma 5-MTHFR when compared to a long-term marker such as BMD, and its deficiency is associated with low BMD that may contribute to the pathogenicity of osteoporosis in postmenopausal women.

Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study

PMID: 15336613


DOI: 10.1016/j.bone.2004.04.018

Abstract

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been well documented to cause hyperhomocysteinemia, and recent studies suggest an association of C677T mutation of methylenetetrahydrofolate reductase with low bone mineral density (BMD). In this study, the association of plasma total homocysteine (Hcy), plasma folate, and vitamin B12 as well as methylenetetrahydrofolate reductase C667T polymorphism with bone mineral density at neck of femur and lumbar spine in 271 postmenopausal Iranian women was investigated. Bone mineral density was measured by dual-energy X-ray absorptiometry. Restriction fragment length polymorphism was used for genotyping the methylenetetrahydrofolate reductase polymorphism. Plasma total homocysteine, plasma folate, and vitamin B12 were also determined. The bone mineral densities at the neck of femur and lumbar spine together with other clinical characteristics among methylenetetrahydrofolate reductase genotypes (CC, CT, and TT) were examined. Bone mineral densities at both neck of femur (r = -0.18, P = 0.003) and lumbar spine (r = -0.16, P = 0.01) were significantly and negatively correlated with the logarithm of plasma total homocysteine. Bone mineral density at the lumbar spine was also significantly and positively associated with plasma folate (r = 0.14, P = 0.02). However, no correlation between methylenetetrahydrofolate reductase polymorphism with bone mineral density at neck of femur (r = -0.01, P = 0.81) and lumbar spine (r = -0.04, P = 0.51) was observed. The negative association of plasma total homocysteine with bone mineral density was no longer significant when adjusted for folate and vitamin B12. Plasma folate and age were the main predictors of plasma total homocysteine explaining 15.3% and 5.2% of the variance of plasma total homocysteine, respectively. Methylenetetrahydrofolate reductase polymorphism, however, was not associated with plasma folate (r = 0.086, P = 0.17) or vitamin B12 (r = 0.05, P = 0.4). Plasma folate was one of the main predictors explaining 3.0% and 1.7% of variance of the bone mineral density at femoral neck and lumbar spine, respectively. Results from this study suggest hyperhomocysteinemia as a result of folate deficiency, but not methylenetetrahydrofolate reductase polymorphism, is independently associated with low bone mineral density and may contribute to the pathogenicity of osteoporosis in postmenopausal Iranian women.

Journal Articles

Association of Mean Arterial Blood Pressure with Plasma Total Homocysteine level, but Not with the Common C677T MTHFR Gene Mutation in Postmenopausal Iranian Women  

Aminzadeh MA, Azizi ZA, Hamidi A, Monjazeb M, Omrani GR, International Journal of Endocrinology and Metabolism, 1/2006

Leptin and Bone Mineral Density in Healthy Postmenopausal Iranian Women 

Shams M, Homayouni K, Hamidi A, Sadegholvad A, Omrani GR., International Journal of Endocrinology and Metabolism, 1/2006

Association of Mean Arterial Blood Pressure with Plasma Total Homocysteine level, but Not with the Common C677T MTHFR Gene Mutation in Postmenopausal Iranian Women

Aminzadeh MA, Azizi ZA, Hamidi A, Monjazeb M, Omrani GR, International Journal of Endocrinology and Metabolism, 1/2006

Abstract/Posters

Tuberculous Thyroiditis Post COVID-19 Infection

Kyaw Zin Win, MD, Afshin Hamidi, MD, Alamgir Sattar, MD, Abhijana Karunakaran, MD, Poster Presentation at ENDO 2021, University at Buffalo, Department of Endocrinology, Diabetes and Metabolism, Buffalo, NY, 3/2021

Weight change with treatment of obstructive sleep apnea

Sharafkhaneh A, Dehghan K, Hamidi A, Hirshkowitz M., European Respiratory Society Annual Congress, Barcelona, Spain, 9/2010